Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on Dec. 22. Who will win?

The San Francisco 49ers could have George Kittle and Ricky Pearsall available for Sunday's prime-time showdown against the Chicago Bears.

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

The San Francisco 49ers play against the Indianapolis Colts in an NFL game tonight. Fans can watch this game for free online.

San Francisco 49ers star tight end George Kittle suffered an ankle injury during Monday night's 48-27 win over the Indianapolis Colts.

The Bears are one of the breakout teams of 2025. They are very likely to win the NFC North after a thrilling Week 16 overtime win against the Packers. The Bears built their record in the first half of the season with a lot of close wins against bad teams, but they have played better over the past month. And they still have a shot at the No. 1 seed.

“Injury Update: George Kittle is questionable to return (ankle),” the team posted on X.

San Francisco 49ers QB Brock Purdy meets with the media to discuss his thoughts from the Colts game, setting a rhythm on offense, and previews the team's Week 18 matchup against the Bears.

The San Francisco 49ers have had a strong showing in 2025, leading to _ of their players getting selected to the 2026 Pro Bowl Games.

The San Francisco 49ers are now in the perfect situation ahead of the playoffs. They are now 11–4 on the season, with two games to go, ahead of a return to the playoffs for the first time since 2023.