Playing defense was optional for the San Francisco 49ers and the Indianapolis Colts on Monday night. The vast majority of the ...

Exploding for 48 points was a terrific way for the San Francisco 49ers to win against the Indianapolis Colts. It was a fun ...

The 49ers beat the Colts on Monday night at Lucas Oil Stadium, and after the game, Kyle Shanahan was especially proud of two ...

By winning Monday night’s final regular-season road game in a 48-27 shootout over the Colts, the 49ers remained in control of ...

The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

The San Francisco 49ers defense finally forced Philip Rivers into a mistake, and the veteran QB wanted to talk about it after ...

A few things were revealed about the 49ers from their win against the Colts that only bode well when the playoffs arrive.

Brock Purdy and the San Francisco 49ers spoiled Philip Rivers' return to Indianapolis, as they took down the Colts to remain ...

Young defenders ignited the 49ers' win. Winters' pick-six and Stout's coverage dominance stole the show in a statement ...

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

The 49ers shouldn’t shy away from the Super Bowl as a goal and they know their pressing issue is Sunday’s visit by the ...