Angelina Jolie shows mastectomy scars to spotlight breast health on TIME France. The Oscar-winning actor appears on the first ...

Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes ...

BRCA1-associated ring domain 1 (BARD1) is the main binding partner of BRCA1 and is essential for the tumour-suppressor functions of BRCA1. The BARD1–BRCA1 heterodimer has ubiquitin ligase activity ...

They are genes commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

The full name of the BRCA1 gene is “breast cancer 1, early onset,” and it codes for a tumor suppressor protein. Tumor suppressor proteins help repair DNA that has become damaged in order to ensure the ...

BRCA1 and BRCA2 are genes that help prevent tumors from growing. If you inherit a change, or mutation, in these genes, they stop doing their jobs, and cancer can develop. In the United States, about 1 ...

Researchers report a new, previously unrecognized function of the BRCA1 gene that explains why BRCA1 gene mutation carriers are at increased risk of breast and ovarian cancer. The human body holds ...

Sometimes the most stunning advances in science are based on a hunch that a dedicated investigator just can’t shake. That was the case with Mary-Claire King, professor of genome sciences and of ...