Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome.

Anaphase-promoting complex / cyclosome (APC/C) is a central gatekeeper of the cell cycle. Although its name suggests that it promotes “anaphase” - a specific step in the cell cycle - APC/C is a large …

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, …

Jul 20, 2014 · The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins to control various events during...

Nov 22, 2017 · The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell …

The anaphase-promoting complex (APC/C) is defined as a large multimeric complex that functions as a RING domain E3 ubiquitin ligase, regulating cell cycle transitions by controlling the ubiquitin …

Aug 9, 2006 · The anaphase promoting complex/cyclosome (APC/C) is the largest known complex that catalyses ubiquitylation reactions and has key functions in the eukaryotic cell cycle.

In this review, we discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis, glial differentiation and migration, neuronal survival and metabolism, neuronal …

Oct 23, 2023 · Mutations in the degradative ubiquitin ligase anaphase-promoting complex (APC) alter neurodevelopment by impairing proteasomal protein clearance, but our understanding of their …

Aug 1, 2025 · The Anaphase-Promoting Complex (APC/C) is a cellular machine found in all eukaryotic cells. It is composed of 11 to 13 protein subunits and plays a fundamental role in orchestrating cell …