Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · This is an impressive study by Serrano-Pozo, Hyman, Das and colleagues that explores astrocyte transcriptomic molecular programs in aging and Alzheimer’s Disease. …
Alleviating symptoms of neurodegenerative disorders by astrocyte ...
Oct 4, 2023 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach …
Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · Two different reactive astrocyte clusters showed enrichment for genes that were positively correlated with the degree of p-tau pathology, suggesting that these astrocyte …
GPCR signaling gates astrocyte responsiveness to …
Jun 6, 2025 · Collectively, these papers highlight the critical and diverse roles of astrocytes in mediating the effects of norepinephrine, and related neuromodulators such as tyramine and …
Astrocyte reactivity influences amyloid-β effects on tau
Jun 2, 2023 · Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 Jul;29 (7):1775-1781. Epub 2023 May 29 PubMed.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Transcriptomics study surveyed six brain regions in people with or without AD. Reelin-expressing neurons were less abundant in AD. Vulnerable neurons in different brain …
“iAssembloids” Probe Glial Roles in Neuron Survival | ALZFORUM
Jan 24, 2025 · To learn what astrocyte ApoE4 might be doing, the scientists compared iAssembloids in which astrocytes expressed ApoE4 with those containing astrocytes that …
Do Microglia and Astrocytes Fuel the Alzheimer’s Cascade?
Nov 8, 2025 · In Alzheimer’s disease, astrocyte reactivity rises with amyloid. But only when microglia are activated. When both glial cells are riled, tau tangles and cognitive decline follow.
Perineuronal Pockets Prevent Spillage from Synapses - ALZFORUM
Jul 23, 2024 · In wild-type mice, tiny pockets in this perineuronal net give astrocytes access to interneuron synapses, the authors report. The pockets also corralled glutamate and other …