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Oxygen-hemoglobin dissociation
Rightward shift of the curve (facilitates unloading of oxygen in the tissues): "CADET, face Right!": High pCO2 Acidosis High 2,3-DPG (anemia or chronic arterial hypoxemia) Exercise Temperature, hyperthermia Leftward shift of the curve (higher affinity for O2): Low pCO2 Alkalosis Low 2,3-DPG (septic shock) Hypothermia
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